• Age at enrollment ≥18 years

• Objective evidence of a proximal filling defect in at least one main or lobar pulmonary artery

• High-risk class of acute PE

• RV dysfunction, as defined RV/LV ratio ≥1.0

• Willing and able to provide informed consent, or if unable, through a Legal Authorized Representative, with permitting research without prior consent as a third option (for Europe and UK sites only), provided compliance with IRB/EC approvals and adherence to regulatory, ethical and national standards